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ered to be stunned by moderate ischemia and subject to salvage if blood ow is restored in a certain period of time As with all infarction, the duration of ischemia plays a role Olsen and colleagues have been able to demonstrate hypoperfused penumbral zones but, interestingly, found that regions just adjacent to them are hyperperfused Furthermore, these investigators and others have shown that elevating the systemic blood pressure or improving the rheologic ow properties of blood in small vessels by hemodilution improves ow in the penumbra; however, attempts to use these techniques in clinical work have met with mixed success The phenomenon of cerebrovascular autoregulation is appropriately introduced here Over a range of mean blood pressures of approximately 50 to 150 mm Hg, the small pial vessels are able to dilate and to constrict in order to maintain CBF in a relatively narrow range This accommodation eventually fails at the extremes of blood pressure, after which CBF follows systemic pressure passively, either falling precipitously or rising to levels that damage small vessel walls The conditions in which the limits of autoregulation are exceeded are at the extremes of hypertensive encephalopathy at one end and circulatory failure at the other, both of which are discussed in later sections of the chapter asp.net c# pdf viewer control open pdf file in another tab. ASP.NET - NullSkull.com
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